Use of ovary culture techniques in reproductive toxicology

Use of ovary culture techniques in reproductive toxicology.

There is increasing evidence to indicate that a substantial number of both man-made and naturally occurring chemicals are disruptive to human and wildlife reproductive health. Currently, reproductive toxicology testing is primarily carried out in vivo, however, in the past 50 years, various culture methods have been developed with the aim of growing ovarian follicles in vitro. These culture sys...

The use of rabbits in male reproductive toxicology.

The rabbit is the smallest and least expensive laboratory animal in which serial semen samples can be obtained for morphologic, biochemical, and fertility evaluation. The female rabbit has a predictable reproductive cycle and can be artificially inseminated with a known amount of sperm during fertility testing. These advantages make the rabbit an extremely valuable model for studying the effect...

Reproductive toxicology.

Stress proteins in reproductive toxicology.

Although a wide range of physical and chemical agents disrupt gametogenesis and embryogenesis in animals and humans, much less is known about the mechanisms leading up to these disruptions and the factors that determine whether a particular animal or human will be sensitive to a potential toxicant. Recent research has identified a number of different stress protein families, also known as heat ...

Reproductive toxicology. Chemical mixture.

Background: Intestinal failure is the outcome of a number of gastrointestinal diseases and characterized by significant reduction in functional gut mass. If not resolved patients often face longterm nutritional support. This study gathered information about how patients referred with intestinal failure are managed in specialised European centres. Methods: A questionnaire was circulated in 7 Eur...